Repeated facial movements like squinting, frowning, or raising your eyebrows can cause lines to settle into your skin over time. These lines, often referred to as dynamic wrinkles, tend to form around the eyes, forehead, and mouth as the skin loses elasticity with age. While they may start out as temporary creases, they can gradually become more visible.
Injectable products can help reduce the appearance of these wrinkles by targeting the muscles beneath the skin. At the office of Mimi Lee M.D. PA in Little Rock, AR, we offer Letybo, a neuromodulator from Hugel Aesthetics, now available in the United States.
About Letybo
Letybo was first produced in South Korea in 2016, and more than 31 million treatments have been performed worldwide since. It launched in the U.S.A. in March 2025. Letybo is known for its QUICK onset, with it working as early as day 1 and typically within 3 days. It has consistent and enduring effects that may last up to 4 months.
During my conference trip to Seoul in 2024, I learned a lot about K-Beauty philosophy. They view skin care as part of their overall healthcare. Skincare is not just done to correct a problem. It is part of the daily routine to take care of your skin so you won’t develop a problem (or wrinkle). Hence, their cosmetic industry is extremely innovative and competitive. There are at least three neurotoxin brands made in a country that is ¾ the size of the state of Arkansas. Letybo is the number one neurotoxin in South Korea and will definitely create a buzz here, along with other K Beauty products.
What Is Letybo?
Letybo is a neuromodulator made by Hugel Aesthetics, a company with years of experience in aesthetic medicine abroad that recently entered the U.S. market. Like other neuromodulators, it contains botulinum toxin type A, which affects the way certain muscles in the face contract. It offers another option for patients seeking temporary improvement in lines caused by repeated facial movements. Each formulation of botulinum toxin has its own clinical properties, and Letybo is specifically processed to create a consistent and smooth injectable product.
How Does Letybo Work?
When injected into specific facial muscles, Letybo interrupts the signals between nerves and the muscles they control. This reduces the activity of muscles responsible for movement-related wrinkles, allowing the skin above them to look smoother. The results do not happen immediately, but you can start to see results within several days. We can adjust the timing of your treatments based on how long your results last and how your muscles respond.
What Can Letybo Treat?
Letybo treats dynamic facial wrinkles caused by repeated expressions like frowning, squinting, and raising the eyebrows. It is FDA-approved for glabellar lines, but we may also use it in off-label areas such as forehead lines and crow’s feet, depending on your facial anatomy. We always assess muscle strength, skin texture, and how your facial muscles interact before selecting injection points.
Before & After gallery
Letybo vs. Botox® and Other Neuromodulators
Letybo is a botulinum toxin type A product, just like Botox, Dysport®, and others. These are all neuromodulators that block nerve signals to soften expression lines. I often explain it like choosing a cola—you have Coke, Pepsi, and RC. They all fall under the same category but offer slight differences in feel, taste, or brand preference.
With neuromodulators, the differences can come down to onset time, spread, and how your muscles respond to each formulation. Letybo has shown a smooth consistency that some patients find appealing, and it performs similarly to Botox in terms of results and duration. Some patients may respond slightly better to one brand over another, which is why we sometimes try different products to see what works best for you.
The Benefits of Letybo
Consistency and Purity
Letybo is processed using advanced filtration techniques that produce a highly purified form of botulinum toxin type A. This results in a consistent product with minimal protein content, which may reduce the risk of developing resistance. Its purity also allows for predictable outcomes when injected into targeted muscles.
Smooth Injection Experience
The texture and viscosity of Letybo allow for smooth and precise injections. We find that the product handles well during treatment, which helps with accuracy in placement. This can be especially helpful when treating smaller facial muscles or fine lines that require detailed control.
Global Performance
Letybo had been widely used in other countries long before becoming available in the U.S., with millions of treatments performed internationally. Developed by Hugel Aesthetics, the product has a strong international track record. Its expansion into U.S. practices gives patients access to a well-established alternative in the neuromodulator category.
Who May Be a Good Candidate for Letybo
Adults With Moderate to Severe Glabellar Lines
Patients who have noticeable vertical lines between the eyebrows that do not fade when the face is at rest may benefit from Letybo. We evaluate muscle activity and skin condition to determine how effective a neuromodulator treatment may be for you.
Individuals Seeking Wrinkle Treatments Without Surgery
Letybo offers a non-surgical method for smoothing facial lines. If you are looking to address dynamic wrinkles without downtime or anesthesia, this may be a good choice. The treatment is quick, and patients typically return to normal activity the same day.
First-Time Injectable Users
If you are new to wrinkle treatments, Letybo provides a gentle introduction to neuromodulators. As with other neuromodulators, you are not committing to permanent changes. We walk you through the process and keep the treatment plan simple so you feel comfortable throughout.
Experienced Patients Exploring New Options
Patients who have used Botox or other neuromodulators may be interested in trying Letybo to compare results. Some notice subtle differences in feel or duration and prefer to switch depending on how their facial muscles respond.
Who May Not Be a Candidate for Letybo
Patients with certain neuromuscular conditions, such as myasthenia gravis or Lambert-Eaton syndrome, should not receive neuromodulator treatments like Letybo. If you have a known allergy to any of the ingredients in the product, we will recommend an alternative approach. We will review your medical history in detail to determine whether this treatment is appropriate for you.
What to Expect Before Your Letybo Treatment
Consultation and Evaluation
We begin by reviewing your medical history, muscle activity, and skin condition to determine whether Letybo is appropriate for your concerns. During the consultation, we examine the strength and movement patterns of your facial muscles to identify where injections may be most effective. We also discuss your treatment goals and any prior experiences with neuromodulators to help customize your approach.
Letybo Pre-Treatment Preparation
Before your appointment, we may recommend avoiding blood-thinning medications or supplements like aspirin, fish oil, or vitamin E for several days, unless prescribed for medical reasons. This can help minimize bruising at the injection sites. For patients who bruises easily, we recommend you begin taking Arnicare® several days before your treatment to further minimize bruising and swelling. It is also helpful to arrive with clean skin or we will lightly remove your makeup and clean with alcohol prior to injections at the treatment zones.
Optional Topical Anesthetic
Dr. Lee is very precise and gentle and uses an ice cube to temporarily numb just prior to the Letybo injections. We also offer topical numbing cream if you prefer. Please let us know in advance since it will take 20 to 30 minutes to begin working and can make the treatment more comfortable.
What Your Letybo Treatment Will Be Like
Determining the Injection Points
We begin by asking you to make certain facial expressions so we can observe how your muscles move and where the wrinkles form. Based on this, we mark precise injection sites that target the muscles responsible for your dynamic lines.
Cleansing the Skin
Before we begin, we clean the skin thoroughly to reduce the chance of irritation or infection. This step also removes any residual oils, skincare products, or makeup that could interfere with the treatment.
Applying Topical Anesthetic
To help you receive injections without any discomfort, we will apply a topical numbing cream to the skin. This takes a few minutes to begin working and can make the treatment more comfortable.
Injecting Letybo
We use a fine needle to inject small amounts of Letybo into each marked point. The actual injections only take a few minutes. The number of injections depends on the treatment area and your individual muscle activity.
Aftercare and Post-Treatment Tips for Letybo
- Stay Upright: Remain upright for 2 hours after your treatment. Lying down too soon may cause the product to shift away from the intended injection sites, which could affect your results.
- Avoiding Touching the Treatment Area: You may gently dab on makeup or skincare products. Do not press, rub, or massage the treated areas for at least 2 hours.
- Skip Exercise and Heat: Avoid intense physical activity, saunas, hot tubs, or direct heat exposure for the rest of the day. Increased blood flow and sweating may cause late bleeding or bruising. It may also interfere with how the product settles and could affect your outcome.
- Continue Taking Arnicare: If you have any bruising, you can take Arnicare tablets for several days to help bruising resolves more quickly.
- Apply Ice: If you have any swelling from the injections, you can apply ice to the area.
How to Maintain Your Letybo Results
- Schedule Repeat Treatments on Time: Results fade gradually, so consistent treatments every few months can help keep lines from becoming more pronounced again. Waiting too long may allow muscle strength and wrinkles to return fully.
- Minimize Excessive Sun Exposure: Because UV damage can accelerate skin aging and may reduce the appearance of smoothness between treatments, we recommend that you use daily sunscreen and protective clothing to help maintain skin quality.
- Follow a Regular Skincare Routine: Cleansing, moisturizing, and using ingredients like peptides or retinoids may support skin health and improve overall appearance. Healthy skin often responds better to neuromodulators and maintains a smoother texture longer.
- Stay Hydrated and Maintain a Balanced Diet: Eating nutrient-rich foods and drinking enough water may contribute to longer-lasting effects because they can contribute to the hydration, health, and elasticity of your skin.
- Avoid Smoking: Smoking accelerates skin aging and may reduce circulation, which can affect how your skin responds to injectable treatments. Avoid tobacco to help prolong the appearance of smoother skin.
Common Questions About Letybo
How Long Do Results Last?
Most patients see results from this neuromodulator last between three and four months, though individual variation is normal. Your body gradually metabolizes the product, and the treated muscles slowly regain movement. If you receive regular treatments at consistent intervals, you may notice that results last longer as your muscles stay relaxed.
Can I Combine Letybo With Other Treatments?
We may combine Letybo with other aesthetic treatments depending on your goals. Dermal fillers can be used alongside neuromodulators to restore volume or define features. We may also recommend skin treatments to improve tone and texture. During your consultation, we review the full range of options to create a coordinated plan based on your skin and facial anatomy.
How Much Does Letybo Cost?
Pricing for Letybo depends on the number of units needed, which varies based on muscle strength and the number of areas treated. We provide a detailed quote after examining your facial movement and discussing your treatment goals.
Why Choose Our Practice for Letybo?
Dr. Mimi Lee brings over two decades of experience in cosmetic injections and has personally performed thousands of treatments with neuromodulators. Her background in both aesthetic medicine and vein care gives her a detailed understanding of facial anatomy and precise techniques. Patients value her honest approach—she recommends only what is necessary and always takes the time to explain each step. Dr. Lee has been recognized repeatedly for her non-surgical cosmetic work in Arkansas and continues to be a resource for both patients and other physicians. If you are considering Letybo, you will be in the care of a physician known for her clinical expertise and thoughtful, individualized attention.
Ask Us About Letybo for Dynamic Wrinkles
Letybo offers a precise way to target dynamic wrinkles with results that develop gradually and require minimal downtime. At the practice of Mimi Lee M.D. PA in Little Rock, AR, we apply careful technique and draw from years of injectable experience to help patients maintain a natural look while softening expression lines. If you are considering a neuromodulator and want to explore an option recently approved in the U.S., Letybo may be right for you. To schedule a consultation, call (501) 588-7824 or contact us online.